Re-L Mayer is absolutely beautiful, I love her design; her clothes, her hairstyle, the blue eyeshadow. If you look at her original character art, one would wonder if her appearance was in any way inspired by Amy Lee (Evanescence), but it does not seem to be the case.
As for the anime, Ergo Proxy, however, I can’t say I finished it. I started watching it years ago and had trouble plowing through the episodes, and ultimately quit, somewhere short before the end. :(